Selected Peer-Reviewed Publications

Cancer & metabolism

  • Zhang X, Halberstam AA, Zhu W, Leitner BP, Thakral D, Bosenberg MW, Perry RJ (2022). Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity. Cancer & Metabolism 10:21.
    • This study reveals differences in substrate preference between immune hot and immune cold melanoma in vitro and in vivo.
  • Akingbesote ND, Norman A, Zhu W, Halberstam AA, Zhang X, Foldi J, Lustberg MB, Perry RJ (2022). A precision medicine approach to metabolic therapy for breast cancer in mice. Comunications Biology 5:478.
    • This paper presents a mutational approach to predict which tumors will respond to insulin-lowering metabolic therapy for breast cancer, and further shows for the first time that there may be benefit in adding insulin-lowering agents in lean animals in addition to obese.
  • Leitner BP, Givechian KB, Ospanova S, Beisenbayeva A, Politi K, Perry RJ (2022). Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma. npj Precision Oncology 6:8.
    • In this manuscript we demonstrate differential metabolic dependency in lung adenocarcinoma vs. squamous cell carcinoma.
  • Leitner BP, Perry RJ (2020). The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer. JNCI Cancer Spectrum 4(2): pkaa007.
    • Here we demonstrate that BMI correlates positively with tumor glucose uptake in breast cancer but negatively with tumor glucose uptake in non-small cell lung cancer using publicly available human PET-CT data.
  • Nasiri AR, Rodrigues MR, Li Z, Leitner BP, Perry RJ (2019). SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia. Cancer & Metabolism 7:10.
    • This manuscript demonstrates that an SGLT2 inhibitor is effective in obese mouse models of breast and colon cancer due to its insulin-lowering effects.
  • Rabin-Court A, Rodrigues MR, Zhang XM, Perry RJ (2019). Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. PLOS One 14:e0218126.
    • Here we show that responsiveness to insulin – by increasing glucose uptake and oxidation in tumor cells in vitro is a hallmark of obesity-associated tumors.
  • Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ (2018). Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Reports 24:47-55.
    • This study, the first cancer paper from the Perry lab, shows that mitochondrial uncoupling with a controlled release mitochondrial protonophore (see Science 2015 paper below) slows colon cancer growth in two obese mouse models.

Metabolic physiology & pathophysiology

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