Selected Peer-Reviewed Publications

Cancer & metabolism

  • Leitner BP, Perry RJ (2020). The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer. JNCI Cancer Spectrum 4(2): pkaa007.
    • Here we demonstrate that BMI correlates positively with tumor glucose uptake in breast cancer but negatively with tumor glucose uptake in non-small cell lung cancer using publicly available human PET-CT data.
  • Nasiri AR, Rodrigues MR, Li Z, Leitner BP, Perry RJ (2019). SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia. Cancer & Metabolism 7:10.
    • This manuscript demonstrates that an SGLT2 inhibitor is effective in obese mouse models of breast and colon cancer due to its insulin-lowering effects.
  • Rabin-Court A, Rodrigues MR, Zhang XM, Perry RJ (2019). Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. PLOS One 14:e0218126. 
    • Here we show that responsiveness to insulin – by increasing glucose uptake and oxidation in tumor cells in vitro is a hallmark of obesity-associated tumors.
  • Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ (2018). Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Reports 24:47-55.
    • This study, the first cancer paper from the Perry lab, shows that mitochondrial uncoupling with a controlled release mitochondrial protonophore (see Science 2015 paper below) slows colon cancer growth in two obese mouse models.

Metabolic physiology & pathophysiology

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