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Selected Perry Lab Publications (including collaborations)

Obesity and cancer

Original research

Akingbesote ND, Norman A, Zhu W, Halberstam AA, Zhang X, Foldi J, Lustberg MB, Perry RJ (2022). Commun. Biol. 5:478.
Marczyk M, Gunasekharan V, Casadevall D, Qing T, Foldi J, Sehgal R, Shan NL, Blenman KRM, O’Meara TA, Umlauf S, Surovtseva YV, Muthusamy V, Rinehart J, Perry RJ, Kibbey R, Hatzis C, Pusztai L (2022). Comprehensive Analysis of Metabolic Isozyme Targets in Cancer. Cancer Res. 82:1698-1711.
Leitner BP, Perry RJ (2020) The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer. JNCI Cancer Spectrum 4:pkaa007.
Nasiri AR, Rodrigues MR, Li Z, Leitner BP, Perry RJ (2019). SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia. Cancer & Metabolism 7:10.
Rabin-Court A, Rodrigues MR, Zhang XM, Perry RJ (2019). Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. PLOS One 14:e0218126.
Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ (2018). Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Reports 24:47-55.

Reviews

Leitner BP, Siebel S, Akingbesote ND, Zhang X, Perry RJ (2022). Insulin and cancer: a tangled web. Biochem. J. 479:583-607.
Fosam A, Perry RJ (2020). Current Mechanisms in Obesity and Tumor Progression. Curr Opin Clin Nutr Metab Care 23:395-403.

Substrate partitioning in stress states

Original research

Qing H*, Desrouleaux R*, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A (2020). Origin and Function of Stress-Induced IL-6 in Murine Models. Cell 182:1660.
Perry RJ*, Resch JM*, Douglass AM*, Madara JC, Rabin-Court A, Kuckdereli H, Wu C, Song JD, Lowell BB⁺, Shulman GI⁺(2019). PNAS 116:13670-13679. * and +, equal contributions.

Metabolic scaling

Akingbesote ND, Leitner BP, Jovin DG, Desrouleaux R, Zhu W, Li Z, Pollak MN, Perry RJ (2022). Gene Expression and Tracer-Based Metabolic Flux Analysis Reveals Tissue-Specific Metabolic Scaling in vitro, ex vivo, and in vivo. bioRxiv 2022.03.02.482685v1.

Method development

Methods utilized by the Perry lab

Schaubroeck KJ, Leitner BP, Perry RJ. An optimized method for tissue glycogen quantification (2022). Physiol. Rep. 10:e15195.
Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI (2017). Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nat. Comm. 8:798.
Perry RJ*, Peng L*, Cline GW, Petersen KF, Shulman GI (2017). A non-invasive method to assess hepatic acetyl-CoA in vivo. Cell Metab. 25:749-56. *Equal contributions.
Perry RJ, Borders CB, Cline GW, Zhang X-M, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI (2016). Propionate increases hepatic pyruvate cycling, anaplerosis and alters mitochondrial metabolism. J. Biol. Chem. 291:12161-70.
Befroy DE*, Perry RJ*, Jain N, Dufour S, Cline GW, Trimmer J, Brosnan J, Rothman DL, Petersen KF, Shulman GI (2014). Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic ¹³C magnetic resonance spectroscopy. Nature Medicine 20:98-102. *Equal contributions.

Metabolism reviews and commentaries

Konkwo C, Perry RJ (2021). Imeglimin: Current Development and Future Potential in Type 2 Diabetes.

Perry lab in the news

Below you’ll find stories involving the Perry lab in the press (Yale and outside); for developments in the lab, please see the Lab News tab.

Dr. Perry and Yale colleagues attend the 2021 Lion Hearts Walk in NYC

7/20/2020: Yale Cancer Answers Podcast: Obesity/Insulin and Cancer
3/4/2020: Yale researchers help restore hormonal balance disrupted in metabolic diseases
2/28/2020: Cancer and Obesity: The Link is Insulin
1/11/2019: YCC Translational Science Research Prize Awarded to Dr. Rachel Perry
7/3/2018: How obesity drives colon cancer in mice

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