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Obesity and cancer
Original research: Perry lab
Leitner BP, Perry RJ (in press). The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer. JNCI Cancer Spectrum . Nasiri AR, Rodrigues MR, Li Z, Leitner BP, Perry RJ (2019). SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia. Cancer & Metabolism 7:10.Rabin-Court A, Rodrigues MR, Zhang XM, Perry RJ (2019). Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. PLOS One 14:e0218126. Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ (2018). Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Reports 24:47-55.Original research: Other groups
Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SK, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC, Yun J (2019). High-fructose corn syrup enhances intestinal tumor growth in mice. Science 363:1345-1349.Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC (2018). Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature 560:499-503.DeCensi A, Puntoni M, Gandini S, Guerrieri-Gonzaga A, Johansson HA, Cazzaniga M, Pruneri G, Serrano D, Schwab M, Hofmann U, Mora S, Aristarco V, Macis D, Bassi F, Luini A, Lazzeroni M, Bonanni B, Pollak MN (2014). Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial. Breast Cancer Res. Treat. 148:81-90.Algire C, Zakikhani M, Blouin MJ, Shuai JH, Pollak MN (2008). Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth. Endocr. Relat . Cancer 15:833-839.Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. NEJM 348:1625-1638.Bastarrachea J, Hortobagyi GN, Smith, TL, Kau SW, Buzdar AU (1994). Obesity as an adverse prognostic factor for patients receiving adjuvant chemotherapy for breast cancer. Ann. Intern. Med. 120:18–25.Reviews
Lennon H, Sperrin M, Badrick E, Renehan AG (2016). The Obesity Paradox in Cancer: a Review. Curr. Oncol. Rep. 18:56.Klil-Drori AJ, Azoulay L, Pollak MN (2017). Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing? Nat. Rev. Clin. Onc ol . 14:85-99.Park J, Morley TS, Kim M, Clegg DJ, Scherer PE (2014). Obesity and cancer—mechanisms underlying tumour progression and recurrence. Nat. Rev. Endo. 10:455-465.Parekh N, Chanran U, Bandera EV (2012). Obesity in cancer survival. Annu. Rev. Nutr. 32:311-342.
Exercise and cancer
Original research
Matthews CE, Moore SC, Arem H, Cook MB, Trabert B, Hakansson N, Larsson SC, Wolk A, Gapstur SM, Lynch BM, Milne RL, Freedman ND, Huang WY, Berrington de Gonzalez A, Kitahara CM, Linet MS, Shiroma EJ, Sandin S, Patel AV, Lee IM (2019). Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk. J. Clin. Onc ol. Moore SC, Lee IM, Weiderpass E, Campbell PT, Sampson JN, Kitahara CM, Keadle SK, Arem H, Berrington de Gonzalez A, Hartge P, Adami HO, Blair CK, Borch KB, Boyd E, Check DP, Fournier A, Freedman ND, Gunter M, Johannson M, Khaw KT, Linet MS, Orsini N, Park Y, Riboli E, Robien K, Schairer C, Sesso H, Spriggs M, Van Dusen R, Wolk A, Matthews CE, Patel AV (2016). Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults. JAMA Intern. Med. 176:816-825.Malicka I, Siewierska K, Pula B, Kobierzycki C, Haus D, Paslawska U, Cegielski M, Dziegiel P, Podhorska-Okolow M, Wozniewski M (2015). The effect of physical training on the N-methyl-N-nitrosourea-induced mammary carcinogenesis of Sprague-Dawley rats. Exp. Biol. Med. 240:1408-1415.Steiner JL, Davis JM, McClellan JL, Enos RT, Murphy EA (2013). Effects of voluntary exercise on tumorigenesis in the C3(1)/SV40Tag transgenic mouse model of breast cancer. Int. J. Oncol. 42:1466-72.Thune I, Brenn T, Lund E, Gaard M (1997). Physical activity and the risk of breast cancer. NEJM 336:1269-1275.Reviews
Rincon-Castanedo C, Morales JS, Martin-Ruiz A, Valenzuela PL, Ramirez M, Santos-Lozano A, Lucia A, Fiuza-Luces C (2020). Physical exercise effects on metastasis: a systematic review and meta-analysis in animal cancer models. Cancer Metastasis Rev .Giovannucci E (2018). An Integrative Approach for Deciphering the Causal Associations of Physical Activity and Cancer Risk: The Role of Adiposity. J. Natl. Cancer Inst. 110:935-941.Stout NL, Baima J, Swisher AK, Winters-Stone KM, Welsh J (2017). A Systematic Review of Exercise Systematic Reviews in the Cancer Literature (2005-2017). PM R. 9:S347-S384.Idorn M, Thor Straten P (2017). Exercise and cancer: from “healthy” to “therapeutic”? Cancer Immunol. Immunother. 66:667-671.
Cancer immunometabolism
Original research
Cascone T, Mckenzie JA, Mbofung RM, Punt S, Wang Z, Xu C, Williams LJ, Wang Z, Bristow CA, Carugo A, Peoples MD, Li L, Karpinets T, Huang L, Malu S, Creasy C, Leahey SE, Chen J, Chen Y, Pelicano H, Bernatchez C, Vashisht Gopal YN, Heffernan TP, Hu J, Wang J, Amaria RN, Garraway LA, Huang P, Yang P, Wistuba II, Woodman SE, Roszik J, Davis RE, Davies MA, Heymach JV, Hwu P, Peng W (2018). Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy. Cell Metab. 27:977-987. Weiss JM, Davies LC, Karwan M, Ileva L, Ozaki MK, Cheng RYS, Ridnour LA, Annunziata CM, Wink DA, McVicar DW (2018). Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. J. Clin. Invest. 128:3794-3805.Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM (2015). Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell 162:1217-1228.Chang CH, Qiu J, O’Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, Van Der Windt GJ, Tonc E, Schreiber RD, Pearce EJ, Pearce EL (2015). Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. Cell 162:1229-1241.Warburg O, Wind F, Negelein E (1927). The metabolism of tumors in the body. J. Gen. Physiol. 8:519-530.Reviews
Substrate partitioning in stress states
Original research
Perry RJ*, Resch JM*, Douglass AM*, Madara JC, Rabin-Court A, Kuckdereli H, Wu C, Song JD, Lowell BB+ , Shulman GI+ (2019). PNAS 116:13670-13679. * and +, equal contributions.Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R (2018). Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. J. Clin. Invest. 128:1485-1495.Sferruzzi-Perri AN, Lopez-Tello J, Fowden AL, Constancia M (2016). Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation. PNAS 113:11255-11260.Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R (2016). Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell 166:1512-1525.Carlton ED, Cooper CL, Demas GE (2014). Metabolic stressors and signals differentially affect energy allocation between reproduction and immune function. Gen. Comp. Endocrinol. 208:21-29.Brauer MJ, Huttenhower C, Airoldi EM, Rosenstein R, Matese JC, Gresham D, Boer VM, Troyanskaya OG, Botstein D (2008). Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast. Mol. Biol. Cell 19:352-367.Reviews
Flux method development
Methods utilized by the Perry lab
Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI (2017). Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nat. Comm. 8:798.Perry RJ*, Peng L*, Cline GW, Petersen KF, Shulman GI (2017). A non-invasive method to assess hepatic acetyl-CoA in vivo . Cell Metab. 25:749-56. *Equal contributions.Perry RJ, Borders CB, Cline GW, Zhang X-M, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI (2016). Propionate increases hepatic pyruvate cycling, anaplerosis and alters mitochondrial metabolism. J. Biol. Chem. 291:12161-70.Befroy DE*, Perry RJ*, Jain N, Dufour S, Cline GW, Trimmer J, Brosnan J, Rothman DL, Petersen KF, Shulman GI (2014). Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13 C magnetic resonance spectroscopy. Nature Medicine 20:98-102. *Equal contributions.
Metabolic scaling
Original research
Thommen A, Werner S, Frank O, Philipp J, Knittelfelder O, Quek Y, Fahmy K, Shevchenko A, Friedrich BM, Julicher F, Rink JC (2019). Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians. Elife 8.Makarieva AM, Gorshkov VG, Chown SL, Reich PB, Gavrilov VM (2008). Mean mass-specific metabolic rates are strikingly similar across life’s major domains: Evidence for life’s metabolic optimum. PNAS 105:16994-16999.Reviews
Speakman JR (2005). Body size, energy metabolism and lifespan. J. Exp. Biol. 208:1717-1730.West GB, Brown JH (2005). The origin of allometric scaling laws in biology from genomes to ecosystems: towards a quantitative unifying theory of biological structure and organization. J. Exp. Biol. 208:1575-1592.Kleiber M (1947). Body size and metabolic rate. Physiol. Rev. 27:511-541.
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